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Thanks to funds from ICE, major pieces of equipment required for the studies upon which ICE is founded are maintained as centralized, shared facilities, housed around the Hopkins medical campus and available to scientists in a range of fields. With expert staff who direct their use, the facilities and ICE are benefiting the entire School of Medicine.

Learn more about:

• High Throughput Biology (HiT) Center
• JHMI Microarray Core Facility
• The Proteomics Center
• Chem Core
• Microarray Core for Cancer Research
• Flow Cytometry Center
• Physiology Virus Core Facility
• Molecular Imaging/MRI
• Phenotyping Core
• Stem Cell Resource Center
• Human Stem Cell Core

High Throughput Biology (HiT) Center
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Jef Boeke, Ph.D, Sc.D., Professor, Director, (410) 955-0398

This center houses the JHMI Microrarray Core Facility, the Proteomics  Center, and the ChemCore described below, as well as the laboratories of several research faculty engaged in high throughput research.

The microarray core currently provides Affymetrix hybridization services, and supports analysis of both Affymetrix and 2-color datasets by individual appointment. Shared seat access to software analysis packages and ftp access to stored microarray datasets are also provided.  Future plans include real time PCR and 2-color hybridization services.

The Microarray Core Facility gratefully acknowledges the receipt of startup funds, space and personnel support from the School of Medicine Office of the Dean, the Institute for Cell Engineering, the Institute of Basic Biomedical Sciences, and the McKusick-Nathans Institute of Genetic Medicine. 

Microarray Core for Cancer Research
Stephen Baylin, M.D., Professor, Chief, Tumor Biology Laboratory, (410) 955-8506  

This second microarray core facility, also supported with ICE funding, serves researchers at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. It provides all the same storehouse capabilities and customized services as the microarray facility described above.  

The Proteomics Center 
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Bob Cole, Ph.D., Instructor, Department of Biological Chemistry, (410) 614-6968

This multimillion dollar facility is one of the only 10 such in the country. Established with a partner grant from the National Heart, Lung and Blood Institute and a Shared Instrumentation Grant from the National Institutes of Health, it used the technique known as mass spectroscopy to sift through thousands of proteins in a single tissue. The proteomics core provides extensive mass spectrometry services for analyzing protein mixtures and purified proteins.  Protein profiling using 2-dimensional gel analysis and fluorescent labeling is also offered.

ChemCore offers a structurally diverse compound repository and high throughput robotics laboratory services.  ChemCore scientists will work with clients to help them optimize their enzymatic and biologic assays for 96 and 384 well format.  A diverse suite of assay options is being developed.

Flow Cytometry Center
Lee Blosser, B.S., Core Manager, (410) 955-7852

The instrumentation in this vital core facility allows researchers to analyze protein expression levels and DNA/RNA content in isolated cells to measure levels for up to seven different proteins in large populations of cells. It can then store the data for subsequent analysis. Based on the levels of protein expression, two high-speed cell sorters additionally let researchers isolate cell populations, analyze them and clone individual cells.

Physiology Virus Core Facility

This technology provides for large scale production and fine tuning of the recombinant adeno-associated virus, allowing researchers to use it as a delivery system for transporting genes.

Molecular Imaging/MRI
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Zaver Bhujwalla, Ph.D., Professor, Departments of Radiology and Oncology, (410) 955-9698

Spectacular advances in the various modalities of noninvasive imaging provide unparalleled opportunities for viewing anatomic, functional and molecular behavior. As a result, technology like MR (magnetic resonance), PET (positron emission tomography) and SPECT (single photon emission tomography) have become powerful tools for investigating various disease processes.

Phenotyping Core
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Cory Brayton, D.V.M., Director Phenotyping Core, (410) 502-3050

The phenotyping core aims to promote functional genomics initiatives at Johns Hopkins by assisting, collaborating and educating in the characterization and use of genetically and phenotypically relevant animal models of disease and gene function by:Providing pathology support and collaboration, including clinical pathology, anatomic pathology, histopathology; Training, educating in evaluation techniques and phenotyping strategies;Coordinating diverse JHMI resources in phenotyping efforts.