Johns Hopkins | Institute for Cell Engineering | Neuroregeneration Program

Blackshaw, S., Harpavat, S., Trimarchi, J., Cai, L., Huang, H., Kuo, W. P., Weber, G., Lee, K., Fraioli, R. E., Cho, S.-H., Yung, R., Asch, E., Wong, W. H., and Cepko, C. L. (2004) Genomic analysis of mouse retinal development. PLoS Biol. 2:E247.

Cai, L., Huang, H., Blackshaw, S., Liu, J. S., Cepko, C. L., and Wong, W. H. (2004) Clustering Analysis of SAGE data: A Poisson Approach. Genome Biology, 5:R51.

Blackshaw, S., Kuo, W. P., Park, P. J., Tsujikawa, M., Gunnersen, J. M., Scott, H. S., Wee- Boon, M., Tan, S. S., and Cepko, C. L. (2003) MicroSAGE is highly representative and reproducible, but reveals major differences in gene expression between samples obtained from identical tissues. Genome Biology, 4:R17.

Blackshaw, S. and Livesey, F. J. (2002). Applying genomic technologies to neural development. Current Opinion in Neurobiology, 6:110-14.

Browne, S. J., Sullivan, L. S., Blanton, S. H., Cepko, C. L., Blackshaw, S., Birch, D. G., Hughbanks-Wheaton, D., Heckenlively, J. R., and Daiger, S. P. (2002). Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa. Hum. Mol. Genet., 11(5):559-568.

Sharon, D*., Blackshaw, S*. Cepko, C. L., and Dryja, T. P. (2002). Profile of the genes expressed in the human peripheral retina, macula, and retinal pigment epithelium determined through serial analysis of gene expression (SAGE). Proc. Natl. Acad. Sci. USA 99:315-20 (* indicates equal contribution by both authors).

Blackshaw, S., Fraioli, R. E., Furukawa, T., and Cepko, C. L. (2001). Comprehensive analysis of photoreceptor gene expression and the identification of candidate retinal disease genes. Cell, 107: 579-89.

Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science. 2002 Jul 12;297(5579):259-63.

Chung KK, Zhang Y, Lim KL, Tanaka Y, Huang H, Gao J, Ross CA, Dawson VL, Dawson TM. Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med. 2001 Oct;7(10):1144-50.

Wildemann B, Haas J, Stingele K, Storch-HagenIocher B, McArthur JC, Dawson TM, Dawson VL. Identification by mRNA differential display of two up-regulated genes as candidate mediators of AIDS dementia. Mol Med. 2001 Mar;7(3):193-9.

Nandagopal K, Dawson TM, Dawson VL. Critical role for nitric oxide signaling in cardiac and neuronal ischemic preconditioning and tolerance. J Pharmacol Exp Ther. 2001 May;297(2):474-8.

Nucifora FC Jr, Sasaki M, Peters MF, Huang H, Cooper JK, Yamada M, Takahashi H, Tsuji S, Troncoso J, Dawson VL, Dawson TM, Ross CA. Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science. 2001 Mar 23;291(5512):2423-8.

Dawson VL. Neurobiology. Of flies and mice. Science. 2000 Apr 28;288(5466):631-2.

Nucifora, F.C. Jr., M. Sasaki, M. F. Peters, H. Huang, J.K. Cooper, M. Yamada, H. Takahashi, H. Tsuji, J. Troncoso, V. L. Dawson, T.M. Dawson*, and C. A. Ross*. "Interference by Huntingtin and Atrophin-1 CBP-Mediated Transcription Leading to Cellular Toxicity." Science, 291: 2423-2428 (2001).

Chung, K.K.K, Y. Zhang, K. L. Lim, Y. Tanaka, H. Huang, J. Gao, C. A. Ross, V. L. Dawson and T. M. Dawson. "Parkin Ubiquitinates the a-Synuclein-Interacting Protein, Synphilin-1: Implications for Lewy Body Formation in Parkinson Disease." Nature Medicine, 7:1144-1150 (2001).

Lee, M.K., W. Stirling, Y. Xu, X, Xu, D. Qui, A.S. Mandir, T.M. Dawson, N.G. Copeland, N.A Jenkins, D.L. Price. “Human a-Synuclein Harboring Familial Parkinson’s Disease Linked Ala53Thr Mutation Causes Neurodegenerative Disease with a-Synuclein Aggregation in Transgenic Mice.” Proc. Natl. Acad. Sci. U.S.A., 99: 8968-8973 (2002).

Dawson, T.M. and V.L. Dawson. “Neuroprotective and Neurorestorative Strategies for Parkinson’s Disease.” Nature Neuroscience, 5:1058-1061 (2002).

Yu, S.-W., H.-M. Wang, M.F. Poitras, C. Coombs, W.J. Bowers, H.J. Federoff, Guy G. Poirer, T.M. Dawson, V.L. Dawson “Mediation of PARP-1 Mediated Cell Death by Apoptosis Inducing Factor.” Science, 297: 259-263 (2002).

Dawson, T.M., A.S. Mandir and M.K. Lee, “Animal Models of PD; Pieces of the Same Puzzle.” Neuron, 35: 219-222 (2002).

Dawson, T.M. and V.L. Dawson. “Molecular Pathways of Neurodegeneration in Parkinson’s Disease” Science, 302: 819-822 (2003)

Li, H., X. Gu, V.L. Dawson and T.M. Dawson. “Identification of Calcium and Nitric Oxide Regulated Genes by Differential Analysis of Library Expression (DAzLE). Proc. Natl. Acad. Sci. U.S.A., 101: 647-652 (2004).

Hong, S.J., H. Li, K.G. Becker, V.L. Dawson*, and T.M. Dawson*. “Identification and Analysis of Plasticity-Induced Late Response Genes.” Proc. Natl. Acad. Sci. U.S.A., 101:2145-2150 (2004).

Chung, K.K.K., B. Thomas, X. Li, O. Pletnikova, J.C. Troncoso, L. Marsh, V. L. Dawson and T.M. Dawson. “S-Nitrosylation of Parkin Regulates Ubiquitination and Compromises Parkin’s Protective Function.” Science, 304:1328-1331 (2004).

Hong, S.J., T.M. Dawson and V.L. Dawson. “Nuclear and Mitochondrial Conversations in Cell Death: PARP-1 and AIF Signaling.” Trends in Pharmacological Sciences, 25: 259-264 (2004).

Von Coelln, R., B. Thomas, J. M. Savitt, K.L. Lim, M. Sasaki, E. Hess, V.L. Dawson, T.M. Dawson. “Loss of Locus Coeruleus Neurons and Reduced Startle in Parkin Null Mice” Proc. Natl. Acad. Sci. U.S.A., in press (2004).

Mizutani, K., Yoon, K., Zhao, R., and N. Gaiano (2008). NF-kB signaling regulates neurogenesis and laminar fate during neocortical development. Submitted.

Mizutani, K., Yoon, K., Dang, L., Tokunaga, A., and N. Gaiano (2007). Differential Notch signaling distinguishes neural stem cells from intermediate progenitors. Nature 449:351-5.

Ever, L., Zhao, R., Eswarakumar, V., and N. Gaiano (2007). Fibroblast growth factor receptor 2 plays an essential role in telencephalic progenitors. Dev Neurosci. Published online ahead of print, Dec 12, 2007.

Mizutani, K., and N. Gaiano (2006). Chalk one up for 'nature' during neocortical neurogenesis. Nat Neurosci. 9: 717-8.

Dang, L., Yoon, K., Wang, M., and N. Gaiano (2006). Notch3 signaling promotes radial glial/progenitor character in the mammalian telencephalon. Dev Neurosci. 28: 58-69.

Dang, L., Fan, X., Chaudry, A., Wang, M., Gaiano, N.*, and C. Eberhart* (2006). Notch3 activation initiates choroid plexus tumor formation in mice. Oncogene. 25: 487-91. *co-senior.

Yoon, K., and N. Gaiano (2005). Notch signaling in the mammalian central nervous system: Insights from mouse mutants. Nat Neurosci. 8: 709-15.

Duncan, A. W., Rattis, F. M., DiMascio, L. N., Congdon, K. L., Pazianos, G., Yoon, K., Cook, M., Willert, K., Gaiano, N., and T. Reya (2005). Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol. 6: 314-22.

Ever, L., and N. Gaiano (2005). Radial 'glial' progenitors: neurogenesis and signaling. Curr Opin in Neurobiol. 15: 29-33.

Yoon, K., Nery, S., Rutlin, M., Radtke, F., Fishell, G.*, and N. Gaiano* (2004). Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors. J Neurosci. 24: 9497-506. *co-senior.

KERR DA*, Llado J, Shamblott MJ, Maragakis NJ, Irani DN, Crawford TO, Krishnan C, Dike S, Sappington A, Gearhart JD and Rothstein JD. 2003. Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury. Journal of Neuroscience; 23(12):5131-5140.

Darman JS, Backovic S, Dike S, Maragakis NJ, Krishnan C, Rothstein JD, Irani, DN and KERR DA*. 2004. Viral induced spinal motoneuron death is non-cell autonomous and involves glutamate excitotoxicity. Journal of Neuroscience; 24 (34): 7566-75.

Hummers LK, Krishnan C, Casiola-Rosen L, Rosen A, Morris S, Mahoney JA, KERR DA, and Wigley FM. 2004. Recurrent Transverse Myelitis Associates with Anti-Ro (SSA) Autoantibodies. Neurology; 62: 147-149.

James A. Harper, Chitra Krishnan, Jessica S. Darman, Deepa M. Deshpande, Schonze Peck, Irina Shats, Stephanie Backovic, Jeffrey Rothstein, DA KERR*. 2004. Axonal Growth of Embryonic Stem Cell-Derived Motoneurons in vitro and in motoneuron-injured Adult Rats. Proceedings of the National Academy of Science; 101(18): 7123-7128.

Krishnan C , Kaplin AI, Graber JS, Darman JS, and KERR DA. 2005. Recurrent transverse myelitis following neurobrucellosis: Immunologic features and beneficial response to immunosuppression. Journal of Neurovirology; 11 (2): 225-231.

Adam I. Kaplin, Deepa M. Deshpande, Erick Scott, Chitra Krishnan, Jessica S. Darman, Irina Shats, Tara Martinez, Jennifer Drummond, Sonny Dike, Mikhail Pletnikov, Sanjay C. Keswani, Timothy H. Moran, Carlos A. Pardo, Peter A. Calabresi, Douglas A. KERR*. 2005. Interleukin-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder Transverse Myelitis. Journal of Clinical Investigation; 115 (10): 2731-2741.

Douglas KERR*, Chitra Krishnan, Michele L. Pucak, and Jessica Carmen. 2005. The immune system and neuropsychiatric diseases. International Review of Psychiatry; 17(6): 443-449.

Maragakis NJ, Rao MS, Llado J, Wong V, Xue H, Pardo A, Herring J, KERR DA, Coccia C and Rothstein JD. 2005. Glial restricted precursors protect against chronic glutamate neurotoxicity of motor neurons in vitro. Glia; 50 (2): 145-159.

David Irani , Caroline Anderson, Rebekah Gundry , Robert Cotter, Stacy Moore, Douglas KERR , Justin C. McArthur, Ned Sacktor, Carlos Pardo, Melina Jones, Peter Calabresi, and Avindra Nath. 2006. Cleavage of Cystatin C in the Cerebrospinal Fluid of Patients with Multiple Sclerosis. Annals of Neurology; 59: 237-247.

Deepa Deshpande, Yun-Sook Kim, Tara Martinez, Jessica Carmen, Sonny Dike, Irina Shats, Lee L. Rubin, Jennifer Drummond, Chitra Krishnan, Ahmet Hoke, Nicholas Maragakis, Jeremy M. Shefner, Jeffrey D. Rothstein, Douglas KERR. 2006. Recovery from Paralysis in Adult Rats Using Embryonic Stem Cells. Annals of Neurology; 60(1):32-44.

Krishnan C, Kaplin AI, Pardo C, KERR DA and Keswani SC. 2006. Demyelinating Disorders - Update on Transverse Myelitis. Current Neurology and Neuroscience Reports; 6 (3):236-243.

Jessica Carmen, Genevieve Gowing, Jean-Pierre Julien, and Douglas KERR*. 2006. Altered Immune Response to CNS Viral Infection in Mice with a Conditional Knock-Down of Macrophage-Lineage Cells. GLIA ; 54: (71-80).

Mamatha S Nayak, Yun-Sook Kim, Michelle Goldman, Hans S Keirstead, Douglas Anthony KERR*. 2006. Cellular Therapies in Motor Neuron Diseases. Biochimica et Biophysica Acta, special issue Molecular Basis of Disease. 1762 (2006) 1128–1138

Anita Venkataramana, Carlos A. Pardo, Justin C. McArthur, Douglas A. KERR, David N. Irani, John W. Griffin, Peter Burger, Daniel S. Reich, Peter Calabresi, Avindra Nath. 2006. Immune Reconstitution Inflammatory Syndrome in the CNS of HIV infected patients. Neurology. 67(3): 383-388.

Kim YS, Martinez T, Deshpande DM, Drummond J, Provost-Javier K, Williams A, McGurk J, Maragakis N, Song H, Ming G, KERR DA. 2006. Correction of Humoral Derangements from TgSOD1G93A Spinal Cord. Annals of Neurology. 60: (716-728).

Greenberg BM, Thomas KP, Krishnan C, Calabresi PA, Kaplin AI, KERR DA. 2006. Management of Transverse Myelitis: A study of steroids, plasma exchange and cyclophosphamide. Neurology. In press.

Ming, G-l., and Poo, M-m. (2003). Attractive and repulsive signaling in nerve growth cone navigation. Handbook of Cell Signaling, Vol 2, p871-875.

Ming, G-l., Wong, S. Henley, J. Yuan, X-b., Song, H-j., Spitzer, N.C. and Poo, M-m. (2002). Adaptation in the chemotactic guidance of nerve growth cones. Nature 417, 411-418 (leading article).

He, Z., Wang, K. C., Koprivica, V., Ming, G-l., Song, H.-J. (2002) Knowing How to Navigate: Mechanisms of Semaphorin Signaling in the Nervous System. Science's STKE, 119RE1.

Ming, G-l., Henley, J., Tessier-Lavigne, M., Song, H-j., and Poo, M-m. (2001). Electrical activity modulates growth cone guidance by diffusible factors. Neuron 29, 441-452.

Ming, G-l., Song, H-j., Berninger, B., Inagaki, N., Tessier-Lavigne, M., and Poo, M-m. (1999). Phospholipase C-g and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance. Neuron 23, 139-48.

Song, H-j*, Ming, G-l.*, He, Z.*, Tessier-Lavigne, M. and Poo, M-m. (1998). Conversion of neuronal growth cone responses from repulsion to attraction. Science 281, 1515-8. (*: equal contribution).

Ming, G-l., Song, H-j., Berninger, B., Holt, C.E., Tessier-Lavigne, M., and Poo, M-m. (1997). cAMP-dependent growth cone guidance by netrin-1. Neuron 19, 1225-1235.

Song, H-j., Ming, G-l., and Poo, M-m. (1997). cAMP-induced switching in turning direction of nerve growth cones. Nature 388, 275-279.

Ming, G-l., Lohof, A.M., and Zheng , J.Q. (1997). Acute morphogenic and chemotropic effects of neurotrophins on cultured embryonic Xenopus spinal neurons. J. Neurosci. 17, 7860-7871.

Goh, E.L.K., Ma, D., Ming, G-l., and Song, H-j. (2003). Adult neural stem cells and repair of the adult central nervous system. Journal of Hematotherapy and Stem Cell Research 12, 671-680.

Song, H-j., Lie, D. C. , Stevens, C.F. and Gage, F.H. (2003). Reply to: Familial dementia with dentate atrophy and failure of neurogenesis. Annals of Neurology 53, 421.

Song, H-j., Stevens, C.F. and Gage, F.H. (2002). Astroglia induce neurogenesis from adult neural stem cells. Nature 417, 39-44 (leading article).

Song, H-j., Stevens, C.F. and Gage, F.H. (2002). Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. Nature Neuroscience 5, 438-45.

He, Z., Wang, K. C., Koprivica, V., Ming, G., Song, H.-j. (2002). Knowing How to Navigate: Mechanisms of Semaphorin Signaling in the Nervous System. Science's STKE, 119 RE1.

Song, H-j., and Poo, M-m. (2001). Cell biology of neuronal navigation. Nature Cell Biology 3, E81-E88.

Song, H-j., and Poo, M-m. (1999). Signal transduction underlying growth cone guidance by diffusible factors. Current Opinion in Neurobiology 4, 355-363.

Song, H-j., Ming, G-l., He, Z., Tessier-Lavigne, M. and Poo, M-m. (1998). Conversion of neuronal growth cone responses from repulsion to attraction. Science 281, 1515-8.

Song, H-j., Ming, G-l., and Poo, M-m. (1997). cAMP-induced switching in turning direction of nerve growth cones. Nature 388, 275-279.

Fitzsimonds, R.M., Song, H-j., and Poo, M-m. (1997). Propagation of activity-dependent synaptic depression in simple neural networks. Nature 388, 439-449 (leading article).

Song, H-j., Ming, G-l., Fon, E., Bellocchio, E., Edwards, R.H., and Poo, M-m. (1997). Expression of a putative vesicular acetylcholine transporter facilitates quantal transmitter packaging. Neuron 18, 815-826