Dr. Linzhao Cheng is a member of the ICE Stem Cell Program.
He holds the academic appointment of associate professor
in Gynecology/Obstetrics and Medicine. He is also a faculty
member of the Graduate Training Programs in Cellular
and Molecular Medicine, Human Genetics and Molecular
Biology, and Immunology.
After receiving a PhD degree in Molecular Biology and
Genetics from Hopkins in 1991, Dr. Cheng has been working
on stem cell research in NIH, the biotech industry and
academia. He has extensive experience in several types
of stem cells: including embryonic stem (ES) cells, hematopoietic
stem cells (HSC), and mesenchymal stem cells/marrow stromal
cells (MSC). In 2003 and nominated by NIH, Dr. Cheng
received the Presidential Early Career Award for Scientists
and Engineers, "for outstanding accomplishments
in the field of stem cell research including pioneering
research that is advancing our knowledge of human embryonic
stem cell self-renewal and differentiation of blood cells".
This Presidential Award is the highest honor bestowed
by the U.S. government on outstanding scientists and
engineers beginning their independent careers.
Dr. Cheng’s ICE laboratory is working on human
stem cell biology and engineering, and their applications
in regenerative medicine. Visit his lab website: www.stemcelllab.org
Publications (since 2003)
- Cheng L , Hammond H, Ye Z, Zhan
X, and Dravid G (2003).
Human adult marrow cells support
prolonged expansion of human embryonic
stem cells in culture. Stem
Cells,
21:131-142.
- Angelopoulou M, Novelli E, Grove
JE, Henry M. Rinder M,
Civin C, Cheng L, Krause DS (2003).
Cotransplantation Of Human Mesenchymal
Stem Cells Enhances Human Myelopoiesis
And Megakaryocytopoiesis In NOD/SCID
Mice. Experimental
Hematology, 7: 413-420.
- Yu X, Zhan X, D’Costa J,
Tanavde VM, Ye Z, Peng
T, Malehorn MT, Yang X, Civin CI
and Cheng L (2003). Lentiviral Vectors
with Two Independent Internal Promoters
Transfer High-Level Expression of
Multiple Transgenes to Human Hematopoietic
Stem-Progenitor Cells. Molecular
Therapy, 7: 827-838.
- McCauslin CS, Wine J, Cheng L,
Klarmann KD, Candotti
F, Clausen PA, Spence SE, Keller
JR (2003). In vivo retroviral gene
transfer by direct intrafemoral injection
results in correction
of the SCID phenotype in Jak3 knockout
animals. Blood,
102: 843-848.
- Cui Y, Kelleher E, Straley E,
Fuchs E, Gorski K, Levitsky
H, Borrello I, Civin C, Schoenberger
S, Cheng L, Pardoll DM, Whartenby
KA. (2003). Immunotherapy of established
tumors using bone marrow transplantation
with antigen gene-modified
hematopoietic stem cells. Nature
Medicine,
9: 952-958.
- Zhou X, Cui Y, Huang X, Yu Z,
Pardoll DM, Jaffee EM,
and Cheng L (2003). Lentivirus-Mediated
Gene Transfer and Expression in Established
Human Cytotoxic T cells
Specific to Tumor antigen and Primary
Unstimulated T Cells. Human
Gene Therapy,
14: 1089-1105.
- Pan F, Ye Z, Cheng L and Liu JO
(2004). MEF-2 mediates
calcium-dependent activation of the
interleukin-2 gene in T lymphocytes. Journal
of Biological Chemistry.
279: 14477-14480.
- Dunlap S, Yu X, Cheng L, Civin
CI, Alani RM (2004).
High-Efficiency Stable Gene Transduction
in Primary Human Melanocytes Using
a Lentiviral Expression System. J
Invest Dermatol. 122: 549-551.
- Zhan X, Dravid G, Ye Z, Hammond
H, Shamblott M, Gearhart
J, and Cheng L (2004). Functional
antigen-presenting leukocytes derived
from human embryonic stem cells in
vitro. The Lancet,
363: 163-171.
- Chen HH, Zhan X, Kumar A, Du X,
Wang D, Cheng L, Yang
X (2004).Detection
of Dual Gene Expression
in Arteries Using an Optical Imaging
Method. J.
Biomedical Optics 9(6):1223-1229.
- Du, X, Qiu B, Zhan X, Kolmakova
A, Gao F, Hofmann LV,
Cheng L, Chatterjee S, Yang XM (2005).
Intravascular MR/Radiofrequency-Enhanced
Vascular Gene Transduction/Expression:
Feasibility Study in Pigs. Radiology 236:
939-944.
- Chou W-C, Chen H-Y, Yu S-L , Cheng
L, Yang P-C, Dang CV
(2005). Arsenic suppresses gene expression
in promyelocytic leukemia cells partly
through SP1 o xidation. Blood,
106: 304-310.
- Dravid G, Ye Z, Hammond H, Chen
G, Pyle A, Donovan PJ,
Yu X and Cheng L (2005). Defining
the role of Wnt/beta-catenin signaling
in the survival, proliferation and
self-renewal of human embryonic stem
cells . Stem Cells,
23: 1489-1501.
- Wang K, Xue T, Tsang SY, Van Huizen
R, Wong CW, Lai KW, Ye
Z, Cheng L, Au KW, Zhang J, Li GR,
Lau CP, Tse HF, Li RA (2005). Electrophysiological
properties of pluripotent
human and mouse embryonic stem cells. Stem
Cells, 23: 1526-1534.
- Yu X, Alder JK, Chun JH, Alan
D Friedman AD, Heimfeld
S, Cheng L, Civin CI (2006). HES1
inhibits cycling of hematopoietic
progenitor cells via DNA-binding. Stem
Cells, 24: 876-888.
- Litvinov IV, Antony L, Dalrymple
SL, Becker R, Cheng L,
Isaacs JT (2006). C3, but not DU145,
human prostate cancer cells retain
the coregulators required for tumor
suppressor ability of androgen receptor. The
Prostate, July 11, online.
- Promoting human embryonic stem
cell renewal or differentiation
by modulating Wnt signal and culture
conditions. Cai L, Ye,
Z, Zhou, BY, Dravid G, Mali P, Zhou
C and Cheng L. Cell Research, in
press.
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