Gregg L. Semenza 

Gregg L. Semenza

Komatsu, D. E., Bosch-Marce, M., Semenza, G. L., and Hadjiargyrou, M.  Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1a deficiency.  J. Bone Mineral Res. 22: 366-374 (2007).

Xu, B., Doughman, Y.-Q., Jiang, W.-H., Turakha, M., Landsettle, C., Agani, F., Semenza, G. L., Watanabe, M., and Yang, Y.-C.  Partial rescue of defects in Cited2-deficient embryos by HIF-1a heterozygosity.  Dev. Biol.  301: 130-140 (2007).

Liu, Y. V., Baek, J. H., Zhang, H., Diez, R., Cole, R. N., and Semenza, G. L. RACK1 competes with HSP90 for binding to HIF-1a and is required for O2-independent and HSP90 inhibitor-induced degradation of HIF-1a. Mol. Cell  25: 207-217 (2007).

Fukuda, R., Zhang, H., Kim, J.-w., Shimoda, L., Dang, C. V., and Semenza, G. L. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells.  Cell 129: 111-122 (2007).

Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, C. V., and Semenza, G. L.  HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity.  Cancer Cell 11: 407-420 (2007).

Baek, J. H., Liu, Y. V., McDonald, K. R., Wesley, J. B., Hubbi, M. E., Byun, H., and Semenza, G. L.  SSAT2 is an essential component of the ubiquitin ligase complex that regulates HIF-1a. J. Biol. Chem. 282: in press (2007).

Tomita, M., Semenza, G. L., Michiels, C., Matsuda, T., Uchihara, J. N., Okudaira, T., Tanaka, Y., Taira, N., Ohshiro, K., and Mori, N.  Activation of hypoxia-inducible factor 1 in human T-cell leukemia virus type 1-infected cell lines and primary adult T-cell leukemia cells. Biochem J. 2007 Jun 19; [Epub ahead of print].

Cai, Z., and Semenza, G. L. Signaling pathways that protect heart against apoptosis induced by ischemia and reperfusion. In: Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volume 2 (R. Srivastava, Ed.), Humana Press Inc., Totowa, NJ, 181-195 (2007).

Semenza, G. L. Interpreting intratumoral hypoxia: Can it guide therapy? Oncology 21:378-384 (2007).

Semenza, G. L.  Hypoxia-inducible factor 1. In: Endothelial Biomedicine (W. C. Aird, Ed.), Cambridge University Press, Cambridge, 236-245 (2007).

Semenza, G. L. Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.  Biochem. J.  405:1-9 (2007).

Liu, Y. V., and Semenza, G. L.  RACK1 vs HSP90: competition for HIF-1a degradation vs stabilization. Cell Cycle  6:656-659 (2007).

Semenza, G. L. Hypoxia and cancer. Cancer Metastasis Rev. 2007 Apr 3; [Epub ahead of print].

Semenza, G. L. HIF-1 mediates the Warburg effect in clear cell renal carcinoma. J. Bionerg. Biomembr. 2007 Jun 6; [Epub ahead of print].